Results for 'Thomas Bl Kirkwood'

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  1.  24
    The free‐radical theory of ageing – older, wiser and still alive.Thomas Bl Kirkwood & Axel Kowald - 2012 - Bioessays 34 (8):692-700.
    The continuing viability of the free‐radical theory of ageing has been questioned following apparently incompatible recent results. We show by modelling positional effects of the generation and primary targets of reactive oxygen species that many of the apparently negative results are likely to be misleading. We conclude that there is instead a need to look more closely at the mechanisms by which free radicals contribute to age‐related dysfunction in living systems. There also needs to be deeper understanding of the dynamics (...)
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  2.  16
    P53 and Ageing: Too Much of a Good Thing?Thomas B. L. Kirkwood - 2002 - Bioessays 24 (7):577-579.
    A recent report by Tyner et al.1 suggests that p53 is bad for longevity. Heterozygotic mice carrying a p53 mutation that apparently enhances the stability of the wild‐type protein showed shorter lifespans and faster ageing while also developing fewer tumours. This fits with the idea that cellular ageing is the price paid for better protection against unlimited proliferation of cancer cells. But other work shows that there is a strong positive association between DNA repair‐mediated protection against cancer and ageing. So (...)
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  3.  5
    The Genetics of Old Age.Thomas B. L. Kirkwood - 2004 - In Justine Burley & John Harris (eds.), A Companion to Genethics. Oxford, UK: Blackwell. pp. 43–50.
    The prelims comprise: Introduction Genetic Architecture of the Life Span Genetics of Longevity Genetics and the Future of Old Age Conclusion.
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  4.  21
    Human senescence.Thomas B. L. Kirkwood - 1996 - Bioessays 18 (12):1009-1016.
    Human life expectancy has increased dramatically through improvements in public health, housing, nutrition and general living standards. Lifespan is now limited chiefly by intrinsic senescence and its associated frailty and diseases. Understanding the biological basis of the ageing process is a major scientific challenge that will require integration of molecular, cellular, genetic and physiological approaches. This article reviews progress that has been made to date, particularly with regard to the genetic contribution to senescence and longevity, and assesses the scale of (...)
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  5.  39
    Evolution of the human menopause.Daryl P. Shanley & Thomas B. L. Kirkwood - 2001 - Bioessays 23 (3):282-287.
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  6.  14
    Book review: Becoming immortal: Combining cloning and stem‐cell therapy. [REVIEW]Thomas B. L. Kirkwood - 2004 - Bioessays 26 (1):106-107.
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  7.  24
    Increasing longevity: an important question, a dubious answer. The evolution of death: Why we are living longer. (2006). By Stanley Shostak. State University of New York Press, Albany 246 pp. ISBN: 07914694689. [REVIEW]Thomas B. L. Kirkwood - 2007 - Bioessays 29 (7):710-711.
  8.  15
    Mitochondria and ageing: winning and losing in the numbers game.João F. Passos, Thomas von Zglinicki & Thomas B. L. Kirkwood - 2007 - Bioessays 29 (9):908-917.
    Mitochondrial dysfunction has long been considered a key mechanism in the ageing process but surprisingly little attention has been paid to the impact of mitochondrial number or density within cells. Recent reports suggest a positive association between mitochondrial density, energy homeostasis and longevity. However, mitochondrial number also determines the number of sites generating reactive oxygen species (ROS) and we suggest that the links between mitochondrial density and ageing are more complex, potentially acting in both directions. The idea that increased density, (...)
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  9.  3
    Biology of ageing.Olivier Toussaint, José Remacle, Brian F. C. Clark, Efstathios S. Gonos, Claudio Franceschi & Thomas B. L. Kirkwood - 2000 - Bioessays 22 (10):954-956.
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  10.  5
    Even when no one is looking: fundamental questions of ethical education.Jan Hábl - 2018 - Eugene, Oregon: Cascade Books.
    This book is not a list or an overview of various theories of ethics. Nor is it a didactic manual for specific teaching units on moral education aimed at some group based on age or a particular theme (although some educational frameworks will be proposed). As the title suggests, the book intends to seek the starting points or foundations without which no moral education would be possible. The goal is to formulate and tackle the key questions that precede all moral (...)
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  11.  12
    Frances McSparran, ed., Octovian Imperator, ed. from MS BL Cotton Caligula A II. Heidelberg: Carl Winter, 1979. Paper. Pp. 123. DM 38. [REVIEW]Thomas J. Heffernan - 1981 - Speculum 56 (2):458.
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  12.  45
    A Way to Interpret Łukasiewicz Logic and Basic Logic.Thomas Vetterlein - 2008 - Studia Logica 90 (3):407-423.
    Fuzzy logics are in most cases based on an ad-hoc decision about the interpretation of the conjunction. If they are useful or not can typically be found out only by testing them with example data. Why we should use a specific fuzzy logic can in general not be made plausible. Since the difficulties arise from the use of additional, unmotivated structure with which the set of truth values is endowed, the only way to base fuzzy logics on firm ground is (...)
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  13.  16
    Shaping Knowledge about American Labor: External Advising at the U.S. Bureau of Labor Statistics in the Twentieth Century.Thomas A. Stapleford - 2010 - Science in Context 23 (2):187-220.
    ArgumentCreated in 1884, the U.S. Bureau of Labor Statistics has been the major federal source for data in the United States on labor-related topics such as prices, unemployment, compensation, productivity, and family expenditures. This essay traces the development and transformation of formal and informal consulting relationships between the BLS and external groups over the twentieth century. Though such a history cannot, of course, provide a comprehensive analysis of how political values have shaped the construction of labor statistics during this period, (...)
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  14.  28
    The Long‐term Unemployed: A New Protected Class of Employee?Thomas A. Hemphill, Waheeda Lillevik & Francine Cullari - 2012 - Business and Society Review 117 (4):535-553.
    Since the onset of the latest United States (U.S.) recession (beginning in December 2007), the U.S. economy has been posting high unemployment levels consistently exceeding 8 percent. Of specific interest, the U.S. Department of Labor, Bureau of Labor Statistics (BLS), reports on a specific subset of the U.S. unemployed: the long‐term unemployed, defined as those who are unemployed for 27 weeks and over. Since December 2009, the share of the long‐term unemployed of the total U.S. unemployed has exceeded 40 percent (...)
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  15.  77
    Residuated lattices arising from equivalence relations on Boolean and Brouwerian algebras.Thomas Vetterlein - 2008 - Mathematical Logic Quarterly 54 (4):350-367.
    Logics designed to deal with vague statements typically allow algebraic semantics such that propositions are interpreted by elements of residuated lattices. The structure of these algebras is in general still unknown, and in the cases that a detailed description is available, to understand its significance for logics can be difficult. So the question seems interesting under which circumstances residuated lattices arise from simpler algebras in some natural way. A possible construction is described in this paper.Namely, we consider pairs consisting of (...)
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  16.  40
    Domestic Religious Themes in Pompeian Painting Thomas Fröhlich: Lararien- und Fassadenbilder in den Vesuvstädten: Untersuchungen zur 'volkstümlichen' pompejanischen Malerei. (Mitteilungen des Deutschen Archäologischen Instituts. Römische Abteilung, Ergänzungsheft 32.) Pp. 370; 11 text-figs., 23 colour pls, 41 bl. and w. pls. Mainz: Von Zabern, 1991. DM 198. [REVIEW]Roger Ling - 1993 - The Classical Review 43 (01):139-141.
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  17.  17
    Thomas Scott of Canterbury (1566–1635): Patriot, civic radical, puritan.Cesare Cuttica - 2008 - History of European Ideas 34 (4):475-489.
    This article sheds new light on the interesting but little-studied figure of Thomas Scott of Canterbury (1566–1635). In presenting Scott's ideas I will modify the interpretation laid out by Peter Clark whose groundbreaking study, ‘Thomas Scott and the Growth of Urban Opposition to the Early Stuart Regime’, is still the only secondary source that pays detailed attention to Scott and his thought, especially his religious opinions. The necessity to revisit Clark's interpretation of Scott's place within the political and (...)
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  18.  13
    Laudatio.Timothy B. Noone - 2010 - Franciscan Studies 68 (1):259-264.
    In lieu of an abstract, here is a brief excerpt of the content:LaudatioTimothy B. Noone (bio)On Sunday, July 26, 2009, the Franciscan Institute was pleased to award to Dr. Girard J. Etzkorn its 22nd Franciscan Institute Medal in recognition of a lifetime of scholarship, editing and publication of texts on medieval philosophy and theology, with a special emphasis on the Franciscan intellectual tradition. The ceremony was held in the Trustees Room of Doyle Hall on the campus of St. Bonaventure University (...)
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  19. Just War and Robots’ Killings.Thomas W. Simpson & Vincent C. Müller - 2016 - Philosophical Quarterly 66 (263):302-22.
    May lethal autonomous weapons systems—‘killer robots ’—be used in war? The majority of writers argue against their use, and those who have argued in favour have done so on a consequentialist basis. We defend the moral permissibility of killer robots, but on the basis of the non-aggregative structure of right assumed by Just War theory. This is necessary because the most important argument against killer robots, the responsibility trilemma proposed by Rob Sparrow, makes the same assumptions. We show that the (...)
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  20. The rationality of belief and other propositional attitudes.Thomas Kelly - 2002 - Philosophical Studies 110 (2):163-96.
    In this paper, I explore the question of whether the expected consequences of holding a belief can affect the rationality of doing so. Special attention is given to various ways in which one might attempt to exert some measure of control over what one believes and the normative status of the beliefs that result from the successful execution of such projects. I argue that the lessons which emerge from thinking about the case ofbelief have important implications for the way we (...)
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  21.  63
    John Dewey and the Moral Imagination: Beyond Putnam and Rorty toward a Postmodern Ethics.Thomas M. Alexander - 1993 - Transactions of the Charles S. Peirce Society 29 (3):369 - 400.
  22. The Rationality of Belief and Some Other Propositional Attitudes.Thomas Kelly - 2002 - Philosophical Studies 110 (2):163-196.
    In this paper, I explore the question of whether the expectedconsequences of holding a belief can affect the rationality ofdoing so. Special attention is given to various ways in whichone might attempt to exert some measure of control over whatone believes and the normative status of the beliefs thatresult from the successful execution of such projects. I arguethat the lessons which emerge from thinking about the case ofbelief have important implications for the way we should thinkabout the rationality of a (...)
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  23.  49
    Dewey and the Metaphysical Imagination.Thomas Alexander - 1992 - Transactions of the Charles S. Peirce Society 28 (2):203 - 215.
  24. Conceiving the impossible and the mind-body problem.Thomas Nagel - 1998 - Philosophy 73 (285):337-52.
    Intuitions based on the first-person perspective can easily mislead us about what is and is not conceivable.1 This point is usually made in support of familiar reductionist positions on the mind-body problem, but I believe it can be detached from that approach. It seems to me that the powerful appearance of contingency in the relation between the functioning of the physical organism and the conscious mind -- an appearance that depends directly or indirectly on the first- person perspective -- must (...)
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  25. How to Endure.Thomas Hofweber & J. David Velleman - unknown
     
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  26.  52
    The Elements of Law, Natural and Politic.Thomas Hobbes - 1969 - New York: Barnes & Noble. Edited by Ferdinand Tönnies.
    Thomas Hobbes (1588-1679) was an English philosopher, remembered today for his work on political philosophy. His 1651 book Leviathan established the foundation for most of Western political philosophy from the perspective of social contract theory. He also contributed to a diverse array of fields, including history, geometry, physics of gases, theology, ethics, general philosophy, and political science. He was one of the main philosophers who founded materialism. He visited Florence in 1636 and later was a regular debater in philosophic (...)
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  27. John Dewey.Thomas Alexander & Richard W. Field - 2003 - In Philip B. Dematteis & Leemon B. McHenry (eds.), Dictionary of Literary Biography. Detroit, USA: Bruccoli-Clark. pp. 56-88.
     
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  28.  10
    The Frankfurt School in Exile.Thomas Wheatland - 2009 - Univ of Minnesota Press.
    Thomas Wheatland examines the influence of the Frankfurt School, or Horkheimer Circle, and how they influenced American social thought and postwar German sociology.
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  29.  38
    Pragmatic Imagination.Thomas M. Alexander - 1990 - Transactions of the Charles S. Peirce Society 26 (3):325 - 348.
  30.  15
    Lectures in set theory.Thomas J. Jech - 1971 - New York,: Springer Verlag.
  31. The prima/ultima facie justification distinction in epistemology.Thomas D. Senor - 1996 - Philosophy and Phenomenological Research 56 (3):551-566.
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  32.  36
    Conceiving the Impossible and the Mind-Body Problem.Thomas Nagel - 1998 - Philosophy 73 (3):337-352.
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  33.  12
    On Heroes, Hero Worship, and the Heroic in History.Thomas Carlyle - 2013 - Yale University Press.
    DIVBased on a series of lectures delivered in 1840, Thomas Carlyle’s On Heroes, Hero-Worship, and the Heroic in History considers the creation of heroes and the ways they exert heroic leadership. From the divine and prophetic to the poetic to the religious to the political, Carlyle investigates the mysterious qualities that elevate humans to cultural significance. By situating the text in the context of six essays by distinguished scholars that reevaluate both Carlyle’s work and his ideas, David Sorensen and (...)
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  34. On trying to save the simple view.Thomas Nadelhoffer - 2006 - Mind and Language 21 (5):565-586.
    According to the analysis of intentional action that Michael Bratman has dubbed the 'Simple View', intending to x is necessary for intentionally x-ing. Despite the plausibility of this view, there is gathering empirical evidence that when people are presented with cases involving moral considerations, they are much more likely to judge that the action (or side effect) in question was brought about intentionally than they are to judge that the agent intended to do it. This suggests that at least as (...)
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  35.  42
    The Supervenience Argument Generalizes.Thomas D. Bontly - 2002 - Philosophical Studies 109 (1):75-96.
    In his recent book, Jaegwon Kim argues thatpsychophysical supervenience withoutpsychophysical reduction renders mentalcausation `unintelligible'. He also claimsthat, contrary to popular opinion, his argumentagainst supervenient mental causation cannot begeneralized so as to threaten the causalefficacy of other `higher-level' properties:e.g., the properties of special sciences likebiology. In this paper, I argue that none ofthe considerations Kim advances are sufficientto keep the supervenience argument fromgeneralizing to all higher-level properties,and that Kim's position in fact entails thatonly the properties of fundamental physicalparticles are causally efficacious.
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  36.  45
    On Trying to Save the Simple View.Thomas Nadelhoffer - 2006 - Mind and Language 21 (5):565-586.
    According to the analysis of intentional action that Michael Bratman has dubbed the ‘Simple View’, intending toxis necessary for intentionallyx‐ing. Despite the plausibility of this view, there is gathering empirical evidence that when people are presented with cases involving moral considerations, they are much more likely to judge that the action (or side effect) in question was brought about intentionally than they are to judge that the agent intended to do it. This suggests that at least as far as the (...)
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  37. The activities of teaching.Thomas F. Green - 1971 - New York,: McGraw-Hill.
  38. The supervenience argument generalizes.Thomas D. Bontly - 2002 - Philosophical Studies 109 (1):75-96.
    In his recent book, Jaegwon Kim argues thatpsychophysical supervenience withoutpsychophysical reduction renders mentalcausation `unintelligible'. He also claimsthat, contrary to popular opinion, his argumentagainst supervenient mental causation cannot begeneralized so as to threaten the causalefficacy of other `higher-level' properties:e.g., the properties of special sciences likebiology. In this paper, I argue that none ofthe considerations Kim advances are sufficientto keep the supervenience argument fromgeneralizing to all higher-level properties,and that Kim's position in fact entails thatonly the properties of fundamental physicalparticles are causally efficacious.
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  39.  20
    Animal Ethics and the Autonomous Animal Self.Natalie Thomas - 2016 - London: Palgrave Macmillan.
    This book presents a radical and intuitive argument against the notion that intentional action, agency and autonomy are features belonging only to humans. Using evidence from research into the minds of non-human animals, it explores the ways in which animals can be understood as individuals who are aware of themselves, and the consequent basis of our moral obligations towards them. The first part of this book argues for a conception of agency in animals that admits to degrees among individuals and (...)
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  40.  12
    John Duns Scotus: Selected Writings on Ethics.Thomas Williams (ed.) - 2017 - Oxford: Oxford University Press.
    Thomas Williams presents the most extensive collection of John Duns Scotus's work on ethics and moral psychology available in English. This accessible and philosophically informed translation includes extended discussions on divine and human freedom, the moral attributes of God, and the relationship between will and intellect.
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  41.  37
    Evolution and ethics.Thomas Henry Huxley - 1896 - Amherst, N.Y.: Prometheus Books. Edited by Thomas Henry Huxley.
    Evolution and ethics. Prolegomena (1894).--Evolution and ethics (1893).--Science and morals (1886).--Capital, the mother of labour (1890).--Social diseases and worse remedies (1891): Preface. The struggle for existence in human society. Letters to the Times. Legal opinions. The articles of war of the Salvation Army.
  42.  42
    Two conceptions of conceptualism and nonconceptualism.Thomas C. Crowther - 2006 - Erkenntnis 65 (2):245-276.
    Though it enjoys widespread support, the claim that perceptual experiences possess nonconceptual content has been vigorously disputed in the recent literature by those who argue that the content of perceptual experience must be conceptual content. Nonconceptualism and conceptualism are often assumed to be well-defined theoretical approaches that each constitute unitary claims about the contents of experience. In this paper I try to show that this implicit assumption is mistaken, and what consequences this has for the debate about perceptual experience. I (...)
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  43.  20
    Norms of Rhetorical Culture.Thomas B. Farrell - 1993 - Yale University Press.
    Rhetoric is widely regarded by both its detractors and advocates as a kind of antithesis to reason. In this book Thomas B. Farrell restores rhetoric as an art of practical reason and enlightened civic participation, grounding it in its classical tradition—particularly in the rhetoric of Aristotle. And, because prevailing modernist world views bear principal responsibility for the disparagement of rhetorical tradition, Farrell also offers a critique of the dominant currents of modern humanist thought. Farrell argues that rhetoric is not (...)
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  44.  52
    The aesthetics of reality : The development of Dewey's ecological theory of experience.Thomas Alexander - 2002 - In F. Thomas Burke, D. Micah Hester & Robert B. Talisse (eds.), Dewey's logical theory: new studies and interpretations. Nashville: Vanderbilt University Press. pp. 3--26.
  45. Selected Philosophical Writings.Thomas Aquinas - 1993 - New York: Oxford University Press. Edited by Timothy S. McDermott.
    St Thomas Aquinas saw religion as part of the natural human propensity to worship. His ability to recognize the naturalness of this phenomenon and simultaneously to go beyond it, to explore spiritual revelation, makes his work fresh and highly readable today. While drawing on a strong distinction between theology and philosophy, Aquinas interleaved them intricately in his writings, which range from an examination of the structures of thought to the concept of God as the end of all things. This (...)
  46. Should we prevent non-therapeutic mutilation and extreme body modification?Thomas Schramme - 2007 - Bioethics 22 (1):8–15.
    ABSTRACT In this paper, I discuss several arguments against non‐therapeutic mutilation. Interventions into bodily integrity, which do not serve a therapeutic purpose and are not regarded as aesthetically acceptable by the majority, e.g. tongue splitting, branding and flesh stapling, are now practised, but, however, are still seen as a kind of ‘aberration’ that ought not to be allowed. I reject several arguments for a possible ban on these body modifications. I find the common pathologisation of body modifications, Kant's argument of (...)
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  47. 1. Front Matter Front Matter (pp. i-ii).Thomas M. Alexander, Robert Cummings Neville, Raymond D. Boisvert, Jacquelyn Anne K. Kegley & Kelly Dean Jolley - 2010 - The Pluralist 5 (2).
     
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  48. The Fourth World of American Philosophy: The Philosophical Significance of Native American Culture.Thomas Alexander - 1996 - Transactions of the Charles S. Peirce Society 32 (3):375 - 402.
  49.  5
    Educational Theory in British Children’s Literary Classics: Teaching and Learning Down the Rabbit Hole.Thomas Albritton - 2021 - Lexington Books.
    This book analyzes iconic British children's literature through the lens of formal educational theory, policy, and practice. Examining themes like growth mindset and project-based learning alongside educational philosophers like Plato, Rousseau, and Dewey, the author sheds new light on children’s classics from Alice in Wonderland to Harry Potter.
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  50.  2
    Selected Writings.Thomas Albrecht (ed.) - 2007 - Stanford University Press.
    Sarah Kofman, Professor of Philosophy at the Sorbonne in Paris and the author of over twenty books, was one of the most significant postwar thinkers in France. Kofman's scholarship was wide-ranging and included work on Freud and psychoanalysis, Nietzsche, feminism and the role of women in Western philosophy, visual art, and literature. The child of Polish Jewish immigrants who lost her father in the Holocaust, she also was interested in Judaism and anti-Semitism, especially as reflected in works of literature and (...)
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